Ibuprofen For The Treatment of Rheumatoid Arthritis and Osteoarthritis Overview
Ibuprofen is both an overthecounter anda prescription medication. The prescription form is used to relieve signs and symptomsof rheumatoid arthritis and osteoarthritis, mild to moderate pain, and is also used totreat primary dysmenorrhea. The prescription ibuprofen comes in a tablet, an oral suspension,and in the injectable forms, and may be taken up to six times per day. It may be taken withfood or milk to avoid stomach irritation. Do not take more than 3.2 grams of ibuprofenper day. Common side effects of prescription ibuprofen include nausea, heartburn, diarrhea,stomach irritation, or headache. It can also cause dizziness. Do not drive or operate heavymachinery until you know how this medication
will affect you. As is always the case, takethis medication only if your healthcare provider prescribes it for you. For RxWiki, I'm LindsayMorrison.
whats a safe dose of prednisone
A spirited debate was published in the Rheumatologist,a magazine I get. The topic was the use of prednisone in rheumatoid arthritis. Recentguidelines produced by the American College of Rheumatology regarding treatment of rheumatoidarthritis omitted the use of prednisone. John Kirwan, a professor at the Universityof Bristol, who wrote several papers showing that prednisone had diseasemodifying effectsand held back the destructive processes of rheumatoid arthritis (RA) made his pitch.He advocated the use of prednisone in combination therapy for this condition. Theodore Pincus, a professor at NYU, advocated the use of low dose prednisone (less thanor equal to 5 mgs a day). He provided evidence
that it was safe and effective at that dose. Anthony S. Russell, a professor at the University of Alberta issued the counterpoint.He provided historical data showing that prednisone had long term toxicity without significantbenefit (in his opinion.) With all due respect to Russell, muchof the data he cited was old data when higher doses of prednisone were used. He also contendedthat primary care s would be tempted to use prednisone if they saw rheumatologistsusing it. My opinion is this. I use low dose prednisonea lot in my practice. By low dose, I mean 5 mgs or less. I think it is effective asan add on therapy. It is also a great quot;bridgequot;
if the patient is transitioning therapies.I have seen very little long term toxicity associated with this low dose approach. AndI think the benefits derived from improved activities of daily living far outweigh thenegatives. I do think that doses higher than 5 mgs should be avoided if possible. I alsodon't think the primary care issue is that big a deal although I admit. I have seensome indiscriminate use in my community.