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Biologic Therapy RA drugs increase surgical infection risk
Surgical Infection Rate Higher with RA DrugsMarianne Wait writing in Arthritis Today reported that people with inflammatory forms of arthritis,such as rheumatoid arthritis, who take more than one traditional disease modifying antirheumaticdrug (DMARD), or a type of biologic drug known as a TNF inhibitor, have an increased riskof infection following orthopaedic surgery, according to a new study published in ArthritisCare Research in December. It is not a new theory that drugs taken forinflammatory arthritis conditions, which in many cases work by suppressing the immunesystem, might increase postsurgical infections. Over the years, a host of studies has lookedat which drugs might elevate the risk and
by how much. The results have not been clear.But this study quot;is one of the best out there regarding this topic,quot; says Tim Bongartz,MD, associate professor of rheumatology at Mayo in Rochester, Minn. Bongartzwas not involved in the study. Based on their results, senior study authorInÃ¨s A. Kramersde Quervain, MD, of the department of rheumatology at the Schulthess inZurich, Switzerland, suggests quot;it may be advisable to consider stopping TNF inhibitors more thanone administration interval before surgery, since the risk of postoperative infectionappears to be higher if the operation occurs within this period.quot; An administration intervalis the length of time between one injection
and the next.
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