We're goingto refer to ankylosing spondylitis as AS. So you don't have to keephearing me say this long thing. But if we go word by word just once, you'll see that ankylosing means fusion. So it describes the spinebeing fused together. Spondy, this first part ofthe word, refers to the spine. and then itis anywhere is inflammation.
So this is an inflammation of the spine and at the sacroiliac joint, actually, and it leads to the fusion of the area. There's some buzz words surrounding it. So one of them would bethat it is the poster child for a group of different diseases that are referred to collectively as the seronegative spondyloarthropathies.
Spondylo, so again, that's the spine, and then arthro, whichrefers to joints in general, and then pathologies or illnesses. So what this means is that they are rheumatoid factor negative. They do not have rheumatoid factor. But they also can appearlike rheumatic joint diseases because it's systemic and itinvolves the immune system.
So speaking of the immune system, the other buzz word you need to know is HLAB17. I'm sorry, I always say that. It's B27. Again, it's part of the immune system. It's an antigen on the surface of the cell that can be recognized by Tcells, which can recruit things to attack it.
So this is the autoimmunecomponent of the disease. This HLAB27 associationactually exists for the seronegativespondyloarthropathies in general, but here, in particular, for AS you should remember that connection. And then, just a littlebackground information on the group of peoplethat tend to get this. Remember, nothing is absolute,
but if we're looking for patterns, it's going to be malesand relatively young ones, actually, really young ones, from 15 to 45 is going to be the meanor the biggest group of people who get AS or that'swhen it's diagnosed the most. So the name kind of tells us what symptoms are characteristic. We have this fusion of the spine.
Inflammatory Autoimmune Infectious Diseases Part 2 Lower Back Pain Spine Expert in Colorado
parkinson's disease occurs in elderly it is noted to be one percent inpopulation over the age of sixty it's associated with tremor muscle rigidity bradykinesia and akinesia difficultywith muscle motion akinesia is the loss of normal
automatic motion such as eye blinking swallowing so patients can drool and have adecreased arms swing when walking many patients will have a pil rollingmaneuver at rest motor strength will be normal eventhough the motion is slow and seventy five percent of patients mayhave unilateral symptoms there is rest tremor present that is a pillrolling
but the voice tremor typically does notoccur and there is a typical gait called a festianation gait the patient tends to take short stepswith the upper body traveling faster than the lower body and a walk will typically turn into arun in advanced diseases charcot marie tooth disease is aninherited disease of peripheral nerves there's actually a number of differenttypes
it's also called peroneal muscle atrophy the myelin sheath and the nerve itselfare both affected and it's both motor and sensory the hallmark of this disease is a cavovarus foot a fancy way ofsaying a very high arch turned in foot with arched toes the picture on the sideis significant for this some individuals have a quote stork legappearance unquote where they have lower leg muscle atrophy
but the upper muscles in the thighs arestill intact ten percent of patients with charcot marie tooth will have a spinal deformity and intrinsicmuscles of the hand can also be involved lyme disease lyme disease is in infectiousneurologic diesease caused by the bite of the deer tick this deer tick will carry the bacteria
borrelia burgdorferi which is a spirochete the onset from the tick bite is about three to thirty two days and eighty percent of patients willexperience a rash called in erythema migrans what they'll see is a small central erythematuous macula or papule that spreads into a larger red ring