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Osteoarthritis vs rheumatoid arthritis pathophysiology
I thought aboutdrawing two different joints to show us the differencebetween rheumatoid and osteoarthritis. But then I thought showingit on the same picture might be easier to see the differences. But on this side we'll keepit rheumatoid arthritis, and the other side, green,will be osteoarthritis. Let's start with thepathophysiology of osteoarthritis
which is overuse. This is where elderlypeople, or people who are carrying a lot of extraweight, or have extra wear and tear on their jointstend to get osteoarthritis. And first thing's first, wehave our joint space here, this is a synovial joint, so it moves. These two bones move against each other. These are gonna be the bone parts.
We're not gonna do very much with them, we care about where they come together. This yellowish layer yousee here, is cartilage. It's kind of a cushionbetween the two bones. We don't want the two bonesto rub against each other. This soft, waxy cartilage,do rub against each other. Now over here we have the synovium, which is a very thin layer of tissue.
And its job is to produce synovial fluid, which is a lubricant of the whole system. Synovium if you look at the word, just as an extra trivia,syn means quot;similar toquot;, and ovium is referring tothe word quot;ovumquot; or quot;eggquot;. So synovial fluidsecreted by the synovium, is this whitish material,very, kind of like the consistency of egg whites.
I think that's where the word came from. Synovium, like egg whites. And that's all filled intheir joint space here, to lubricate the movementsbetween the two bones. So as you can imagine, thissystem allows the bones to move every whichway, gives us movement. Osteoarthritis if I had tosummarize it in two words, I would say it is cartilage destruction.
It is purely mechanical wear and tear of the cartilage layer, this cushioning. So we think of elderlypeople having this problem, but the truth is, thestate of one's cartilage is also genetic, some people have better or more cartilage to begin with. So the age issue aside,just think of it as the destruction ofcartilage layer with time.